The fight against incurable diseases takes, probably, one of the first places in world medical practice. According to official statistics, more than 35 million people on our planet live with the most dangerous disease of the human immunodeficiency virus (HIV). Despite significant progress in the development of maintenance therapy for patients, an HIV drug has not yet been established. But, perhaps, scientists from the Medical School of Lewis Katz managed to get closer to its creation. According to the publication Science Direct with reference to the journal Molecular Therapy, specialists managed to completely destroy a dangerous virus in the cells of infected animals.
Dr. Kamel Khalili is responsible for the development, of which we have already written. Help Dr. Kamel his colleagues – Wenhui Hu, Laura Carnell and Won-Bin Jung. Scientists were able to make a breakthrough thanks to the technology of editing the genome, widely known as CRISPR / Cas9. For their work, the experts used several groups of mice, among which were genetically modified rodents, in whose blood were the human immune cells. These mice were infected with the HIV-1 virus. As commented by Dr. Hu,
"We confirmed the data from our previous work and demonstrated that it is extremely effective. For a new study, we used several groups of animals: one was a carrier of the acute form of the disease, the other was chronic. "
Experts were able to deactivate HIV-1 virus and reduced the expression of RNA virus by 65-95%. In the case of using CRISPR / Cas9 on infected rodents, the method proved effective in 96% of cases. During only one stage of gene editing, the virus segments were completely removed from human cells. Scientists have managed to overcome the virus in the spleen, lungs, heart, intestines and brain of mice. According to the authors of the study, the next stage of their trial is the experiments on primates, and the final goal of the experiment is the commencement of full-fledged clinical trials in humans and the creation of an active medicine.